activating – Communicable Diseases Research

Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activation

Article

Published on 2022-11-012022-11-15
Journal: Veterinary microbiology
[Category] SARS, 유전자 메커니즘, 치료제,

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses

Article

Published on 2022-10-282022-11-16
Journal: Medicine
[Category] meta-analysis, 변종,

[키워드] activating Analysis analysis appraisal checklist conducted COVID-19 vaccination criteria Critical cumulative database Effect effect size eligible endothelial environmental risk factor Epidemiology estimates etiology Evidence Genetic genetic risk factor Genetic variant Genetic variations had more heterogeneity Human identify Intervention meta-analyses meta-analysis MTHFR network p values performed polymorphism protease Protein prothrombin provided receptor respond review risk Risk factors Sample size selected surgical systematic review variable variant Venice venous Venous Thromboembolism VTE was performed were used
[DOI] 10.1097/MD.0000000000031162 PMC 바로가기

The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors

Article

Published on 2022-09-282022-11-15
Journal: Frontiers in Immunology
[Category] 치료제,

[키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombosis. thrombotic event tissue Treatment vessel walls with COVID-19
[DOI] 10.3389/fimmu.2022.955654 PMC 바로가기

Circulating multimeric immune complexes contribute to immunopathology in COVID-19

Article

Published on 2022-09-262022-11-15
Journal: Nature Communications
[Category] SARS, 진단, 치료기술, 치료제,

C-reactive protein, immunothrombosis and venous thromboembolism

Article

Published on 2022-09-132022-11-15
Journal: Frontiers in Immunology
[Category] 바이오마커,

[키워드] activating amplifying appear binding Biomarker C-reactive protein classical Clinical data Clinical practice clinical utility Complement pathway condition conserved COVID-19 CRP destabilized dissociate Effect elevated Elevation Evidence Features immunothrombosis Infection Inflammation Inflammatory bowel disease Inflammatory response isoform marker membrane monomeric Pathogenesis Platelet pro-inflammatory pro-thrombotic Prophylactic Protein raise required Sepsis subset therapeutic strategy Thromboinflammation thrombosis tissue damage triggering utility Venous Thromboembolism venous thromboembolism. VTE VTE risk with COVID-19
[DOI] 10.3389/fimmu.2022.1002652 PMC 바로가기

Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19

Review article

Published on 2022-09-012022-10-05
Journal: Free radical biology & medicine
[Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] activating Activation acute lung injury acute respiratory distress syndrome (ARDS) age aging analysis Anti-inflammatory antioxidant ARDS attenuate Biomarkers Blood oxygen saturation Brain cause caused cellular cellular damage Central nervous system Cholinergic anti-inflammatory pathway chronic inflammation clinical Clinical outcome COVID-19 COVID-19 patient COVID-19 patients death decrease Defense distress dysregulated Effect function functions humans hyperinflammation IMPROVE increase in infected with SARS-CoV-2 infections Inflammation inflammatory lung injury Inflammatory response inhibiting Innate immunity likelihood lung lung cells Lung inflammation macrophages master regulator Mitochondria morbidity and mortality oxidative oxidative stress oxygen Oxygen therapy pathway positive correlation positively correlated Postmortem prolonged exposure Pulmonary infection reactive oxygen specy receiving receptor regulate regulated resulting ROS Safe Sepsis shown Signaling supplemental oxygen Supplemental oxygen therapy susceptibility syndrome Therapeutic approach Toxicity treat α7 nicotinic acetylcholine receptor α7nAChR
[DOI] 10.1016/j.freeradbiomed.2022.08.004 [Article Type] Review article

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다

Article

Published on 2022-08-102022-09-11
Journal: Journal of Virology
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article

GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus

Ganoderma microsporum의 단백질인 GMI는 SARS-CoV-2 Spike-pseudotyped 바이러스의 감염을 완화하기 위해 ACE2 분해를 유도합니다

Article

Published on 2022-08-012022-09-11
Journal: Phytomedicine : international journal of phytother
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression activating addition alleviate bafilomycin blocking Cell cell viability cells cloned Cytometry deaths Degradation determined by downregulated dynamin Effect Efficacy examined exhibit expressing flow cytometry fluorescence microscopy fluorescent function Fungal immunomodulatory proteins fungal protein GFP GMI green fluorescent protein HEK293T host cells Human immunomodulatory immunomodulatory functions in vitro induce infecting Infection inhibited inhibiting Interaction lentiviral lung epithelial lung tissue lysosome macrophages mechanism MG132 mice MTT nebulizer not affect overexpressing pandemic Prevent prevention proteasome Protein protein level pseudovirus reduced rescued respiratory responsible S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2. Severe acute respiratory syndrome spike Spike protein Therapeutic strategies triggered Type Vaccine viability viral infection virus was determined western blot
[DOI] 10.1016/j.phymed.2022.154215 PMC 바로가기 [Article Type] Article

RNA solutions to treat inborn errors of metabolism

신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션

Review

Published on 2022-08-012022-09-11
Journal: Molecular genetics and metabolism
[Category] 유전자 메커니즘,

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과

Article

Published on 2022-07-292022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc
[DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article